Scientists tested a special type of dead bacteria called Fructobacillus fructosus on mice eating high-fat diets. The mice that got this bacteria supplement gained less weight, had healthier livers, and kept their muscles stronger compared to mice that didn’t get it. The bacteria seemed to help the body’s energy factories (called mitochondria) work better in muscles. While this is early research done only in mice, it suggests this type of bacteria supplement might one day help people struggling with weight gain and muscle weakness.

The Quick Take

  • What they studied: Whether giving mice a supplement made from dead bacteria could prevent weight gain and muscle problems when eating a high-fat diet
  • Who participated: Laboratory mice (C57BL/6 strain) that were fed high-fat diets for 13 weeks, with some getting the bacteria supplement
  • Key finding: Mice getting the bacteria supplement gained significantly less weight and had stronger muscles compared to mice without it
  • What it means for you: This early research suggests certain bacteria supplements might help with weight management and muscle health, but human studies are needed before making recommendations

The Research Details

Researchers divided laboratory mice into groups and fed them all high-fat diets designed to cause weight gain and muscle problems. Some mice also received daily doses of heat-killed Fructobacillus fructosus bacteria mixed into their food for 13 weeks. The scientists regularly measured the mice’s weight, took blood samples to check liver and cholesterol levels, and tested muscle strength. At the end, they examined the mice’s tissues under microscopes and analyzed which genes were active in their muscles.

This controlled approach helps scientists understand if the bacteria supplement directly caused the health improvements, rather than other factors. Using mice allows researchers to study effects that would take years to see in humans.

The study was published in Scientific Reports, a respected journal that reviews research before publication. However, this is animal research, which doesn’t always translate to humans, and the sample size appears relatively small.

What the Results Show

Mice receiving the bacteria supplement showed significantly less weight gain despite eating the same high-fat diet as control mice. Their liver health improved dramatically, with lower levels of enzymes that indicate liver damage. Blood tests revealed better cholesterol and fat levels throughout the study period. Most importantly, these mice maintained better muscle strength and showed less muscle weakness compared to mice not getting the supplement.

The researchers found that muscles in supplemented mice had more mitochondria - the tiny power plants that help muscles work efficiently. Gene analysis showed the supplement helped prevent fat from building up inside muscle tissue while promoting the growth of healthy muscle fibers. The mice also showed reduced signs of fatty liver disease, a common problem in obesity.

Previous laboratory studies showed this bacteria could improve mitochondria in muscle cells grown in dishes, but this is the first study to test it in living animals. The results support earlier findings about mitochondrial benefits while revealing new effects on weight and liver health.

This study only tested mice, so we don’t know if humans would respond the same way. The researchers didn’t specify exactly how many mice were used, making it harder to judge how reliable the results are. The study also only lasted 13 weeks, so long-term effects remain unknown.

The Bottom Line

While promising, this research is too early to recommend this specific bacteria supplement for humans. People interested in gut health should focus on proven strategies like eating diverse fiber-rich foods and regular exercise until human studies are completed.

This research may eventually benefit people struggling with weight management and muscle weakness, particularly those with fatty liver disease. However, anyone considering supplements should consult healthcare providers first.

Human clinical trials would likely take 2-5 years to complete before we know if these benefits apply to people. Even then, developing safe, effective supplements could take additional time.

Want to Apply This Research?

  • Track daily fiber intake from diverse plant sources, aiming for 25-35 grams per day to support beneficial gut bacteria naturally
  • Focus on eating a variety of fermented foods like yogurt, kefir, and sauerkraut while maintaining regular strength training to support both gut health and muscle strength
  • Monitor energy levels, muscle strength through simple exercises, and digestive health weekly while building sustainable gut-healthy eating patterns

This research was conducted in mice and has not been tested in humans. Do not use this information to self-diagnose or treat any condition. Always consult with a qualified healthcare provider before starting any new supplement regimen or making significant dietary changes.